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Automotive neck injury indicators in relation to dummy - tram interaction
Ország, Artur ; Jelen, Karel (advisor) ; Tlapáková, Eva (referee)
Title: Automotive neck injury indicators in relation to dummy-tram interaction Objectives The aim of the work is to evaluate the performer crash tests between the dummy and the vehicle in terms of the thread of the health of the neck and to determine which type of tram creates the smallest risk of health of the neck (cervical spine) at the specified speeds. Methods: This diploma thesis is conducted in form of a pilot study. The first part of the work contains theoretical starting points regarding the discussed topic. The second part analyzes the results of the crash tests and answers the research questions and examines the given hypotheses. Results: The most dangerous, concerning the structure of the neck, were collisions in the highest speed - 20 km/h. The highest values and highest probability of injuries with AIS 2+ and 3+ value were measured in this speed. The type of tram that was most dangerous for the structure of the next were T3 and KT8 and the least dangerous was 15T. Keywords: Tram, tram transport, neck, neck injury, crash tests, injury criteria, neck structure
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Morphological and Genomic Profiling of Circulating Tumor Cells in Metastatic Colorectal Cancer
Thiele, Jana-Aletta ; Pitule, Pavel (advisor) ; Mohelníková Duchoňová, Beatrice (referee) ; Kasimir-Bauer, Sabine (referee)
Colorectal cancer (CRC) is the third most common cancer worldwide; it is responsible for nearly 10% of all newly diagnosed cancers and is the second most cause of cancer related death in Europe. Biomarkers for therapy guidance, targeted therapy and survival prognosis are still limited. As CRC is a heterogeneous disease, different parts of the tumor might have varying molecular characteristics which may change during therapy or disease progression. Through solid biopsies and screenings, these local or temporal differences are impossible to monitor. To facilitate detection of these possible temporal changes, a regularly and non-invasively accessible biomarker is required for disease monitoring. Circulating tumor cells (CTCs) might represent such a biomarker as they have been shown to be fluid surrogates of the solid tumor. EpCAM positive CTCs have shown to be prognostic in CRC for survival, but their full potential has not yet been evaluated further. By using the High Definition Single Cell Analysis (HD-SCA) workflow, we were able to analyze the entire spectrum of CTCs and categorize them as the regular CTCs (HD-CTC), CTCs with a smaller nuclear area (CTC-Small), CTCs with low expression of epithelial marker cytokeratin (CTC-LowCK) and CTCs undergoing apoptosis and therefore releasing cell free DNA...
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Morphological and Genomic Profiling of Circulating Tumor Cells in Metastatic Colorectal Cancer
Thiele, Jana-Aletta ; Pitule, Pavel (advisor) ; Mohelníková Duchoňová, Beatrice (referee) ; Kasimir-Bauer, Sabine (referee)
Colorectal cancer (CRC) is the third most common cancer worldwide; it is responsible for nearly 10% of all newly diagnosed cancers and is the second most cause of cancer related death in Europe. Biomarkers for therapy guidance, targeted therapy and survival prognosis are still limited. As CRC is a heterogeneous disease, different parts of the tumor might have varying molecular characteristics which may change during therapy or disease progression. Through solid biopsies and screenings, these local or temporal differences are impossible to monitor. To facilitate detection of these possible temporal changes, a regularly and non-invasively accessible biomarker is required for disease monitoring. Circulating tumor cells (CTCs) might represent such a biomarker as they have been shown to be fluid surrogates of the solid tumor. EpCAM positive CTCs have shown to be prognostic in CRC for survival, but their full potential has not yet been evaluated further. By using the High Definition Single Cell Analysis (HD-SCA) workflow, we were able to analyze the entire spectrum of CTCs and categorize them as the regular CTCs (HD-CTC), CTCs with a smaller nuclear area (CTC-Small), CTCs with low expression of epithelial marker cytokeratin (CTC-LowCK) and CTCs undergoing apoptosis and therefore releasing cell free DNA...
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Czech Republic and its connection to new LNG terminals - strengthening of the gas security
Prouza, Petr ; Kučerová, Irah (advisor) ; Binhack, Petr (referee)
Master thesis "Czech Republic and its connection to new LNG terminals - strengthening of the gas security" examines the level of gas security in the Czech Republic. Dependency of the Czech Republic on gas supplies from foreign countries is almost 100 %. Russian federation is dominant supplier with roughly 75 % of the supplies. High dependency on one exporter is considered hazardous from energy security perspective. The Czech government should strive to change and improve this situation. The diversification is considered as a useful tool to improve the gas security. Currently there are new gas projects built in neighboring countries, which may influence energy security of the Czech Republic. The study researches the impact of these new projects on the Czech Republic. Namely we focused on gas pipeline Nord Stream and its Czech connection Gazelle, which will connect North Germany and Bavaria through the Czech Republic. Second project is gas network called "the North - South Corridor" connecting Baltic and Adriatic Sea. The North - South corridor may be potentially linked up to the new LNG terminals Świnoujście in Poland or Adria in Croatia. Furthermore, there are long-lasting plans to open new "South" gas route from Caspian region to Europe. The main goal of this thesis is to explore real...
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Porovnání senzorické jakosti masa z konvenčního a ekologického chovu
Fiebichová, Aneta
Bachelor thesis presents a comparison of the sensory quality of meat from conventional and ecological breeding. The introduction describes the main characteristics of conventional and ecological agriculture and their basic differences. In the next chapter are defined the basic breeds of beef cattle used in ecological and also on conventional agriculture. It describes the main characteristics, origin, meat efficiency and breeding requirements. Futhermore, the work focuses on breeding of beef cattle in both - economical and conventional agriculture, especially in terms of prevention and welfare, housing, feeding and water feeding. It also deals with the transport of beef cattle for slaughter and eventual housing. Next chapter is focused on the relevant legislation. Also sensory evaluation was made - the evaluators rated the meat samples from conventional and ecological breeding in terms of color, juicy, fibrous, taste, smell and fragility. From each breeding were collected three samples from neck, shoulder and shin. Sensory analysis showed that better sensory characteristics have samples of meat from the shoulder and shin of conventional breeding. Samples of meat from the neck showed better sensory characteristics of ecological breeding.
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